|English.news.cn 2012-11-16 07:43:03|
Scientists at the University of Texas MD Anderson Cancer Center and Texas Heart Institute at St. Luke's Episcopal Hospital have discovered how the drug, doxorubicin, attacks the heart, opening potential new options to prevent or minimize the drug's life- threatening side effects, according to the online edition of Texas Medical Center News released Thursday.
Doxorubicin, brand names Adriamycin and Rubex, is a 50-year-old chemotherapy drug still widely used against a variety of cancers, including breast, ovarian, lung and bladder cancers as well as leukemia and lymphoma. "However, its use is limited by its cardiotoxicity. We're excited because we've identified the molecular basis for doxorubicin's damage to the heart," said Edward T.H., chair of MD Anderson's cardiology department and senior author of the study.
Understanding the steps the drug takes when attacking the heart can help researchers identify those patients who are sensitive to heart damage by doxorubicin, Yeh was quoted as saying. "Once identified, those patients can be placed on alternative cancer drugs, or on special drugs to protect the heart," Yeh added.
Yeh and his colleagues showed that when a protein known as Top2b was eliminated in the heart muscles of laboratory mice, the mice were protected against and avoided heart damage from the toxic side effects of doxorubicin.
This finding suggests that Top2b triggers the drug's effect on cancer patients, said Yeh.
"This is obviously a significant finding," he said, "and one with the potential to help scientists develop a blood test to predict patients' sensitivity to this drug, and to completely eliminate its dreaded side effects."
Researchers from the Shanghai Jiao Tong University School of Medicine in China and the Robert Wood Johnson Medical School in New Jersey also participated in the study, said the report.
Editor: Yamei Wang
Are you ready for 'Malunggay' as national vegetable?
(philstar.com) Updated September 14, 2012 09:32 AM
MANILA, Philippines - Malunggay may soon be declared as the national vegetable of the Philippines and the month of November as the “National Malunggay Month.”
Rep. Ma. Georgina De Venecia (4th District, Pangasinan), author of House Bill 6462, said Malunggay (Moringa Oliefera), dubbed as a “miracle vegetable or nature’s medicine cabinet” by scientists and health care workers from around the world, is loaded with vitamins and minerals that can be an effective remedy against many kinds of ailments.
“From the roots and branches to the leaves, flowers, fruit and seeds, all parts of the Malunggay tree are of nutritive and medicinal value,” De Venecia said.
De Venecia cited a report by the Biotechnology Program Office of the Department of Agriculture that Malunggay has been found by biochemists and molecular anthropologists to be rich in vitamins C and A, iron, and high density lipoprotein or good cholesterol.
De Venecia said Malunggay is also considered as an effective cure for illnesses such as diabetes, hypertension, inflammations, infections, cancer and aging issues.
She said Malunggay leaves alone contain a powerhouse of nutritional value: seven times the vitamin C in oranges, four times the calcium in milk, four times the vitamin A in carrots, twice the protein in milk and three times the potassium in bananas.
Furthermore, Malunggay contains more than 90 nutrients and 46 types of antioxidants. It has 18 amino acids, plenty of omega 3 oils and chlorophyll, plus 45 compounds with antioxidant properties and 36 anti-inflammatory properties, she added.
Malunggay tress can also help stablize the soil and contribute to the fight against deforestation.
“Our country is presently expanding the local market for Malunggay and its by-products with the aim of enhancing the agribusiness potentials of various crops as part of the government's poverty-alleviation and health care programs,” De Venecia said.
“Now we can say that Malunggay can save lives, increase incomes, generate millions of jobs, utilize vast tracts of idle agricultural lands, and help attain ocioeconomic equity,” De Venecia added.
She said Malunggay is one of the most important plants that deserve national and international promotion and support due to the many biomedical endowments and numerous socio-economic benefits that can be derived from it.
Malunggay as National Vegetable Proposed
By BEN R. ROSARIO
Manila, Philippines – Malunggay or horse radish tree, a widely common tree in the country that is also known as “nature’s medicine cabinet,” should be declared as the Philippines’ national vegetable, Pangasinan Rep. Ma. Georgina de Venecia said yesterday.
De Venecia, wife of former House Speaker Jose C. de Venecia Jr., made the endorsement as she filed House Bill (HB) No. 6462 that also seeks to declare November as “National Malunggay Month.”
Also known as moringa or benzolive tree, the leaves of malunggay (moringa oliefera) have been proven by scientists and herbal medicine practitioners to contain vitamins and minerals that are vital to human health.
Aside from the nutritional value of the leaves, health workers also endorse malunggay as an effective remedy against a number of ailments.
“From the roots and branches to the leaves, flowers, fruit, and seeds, all parts of the malunggay tree are of nutritive and medicinal value,” De Venecia said.
Citing a report by the Biotechnology Program Office of the Department of Agriculture, De Venecia said biochemists and molecular anthropologists have discovered that malunggay is rich in Vitamins C and A, iron, and high density lipoprotein or good cholesterol.
De Venecia added that extracts from leaves and the seed pods known as drumsticks are effective against diabetes, hypertension, inflammations, infections, aging problems, and even cancer.
She said the leaves alone contain a powerhouse of nutritional value: Seven times the Vitamin C in oranges, four times the calcium in milk, four times the Vitamin A in carrots, twice the protein in milk, and three times the potassium in bananas. Furthermore, malunggay contains more than 90 nutrients and 46 types of antioxidants. It has 18 amino acids, plenty of Omega 3 oils and chlorophyll, plus 45 compounds with antioxidant properties and 36 anti-inflammatory properties, she added.
In terms of environmental value, malunggay tress can also help stablize the soil and contribute to the fight against deforestation.
New Study Shows Moringa Oleifera Scores Highest Antioxidant Content in Food
Moringa Source's Moringa Powder Sets New Record for Most Antioxidant Rich Food in Independent Test
NEWTOWN, CT, June 28, 2012 --/PRNewswire-iReach/ -- In an independent test, Moringa oleifera scored the highest in antioxidant content of any food yet discovered. Beating the record-holding acai berry by over a 50% margin, Moringa Source Moringa oleifera leaf powder measured over 157,000 umoles using the Oxidant Radicals Absorbent Capacity (ORAC) system of measurement developed by the National Institute of Health's National Institute for Aging.
"We are very encouraged by the ORAC results because it signifies Moringa Source Moringa oleifera leaf powder has twice the radical-quenching power of Baobab and several other superfoods making it the most antioxidant-potent food on the planet," said Jim Fitzpatrick, co-founder ofMoringa Source, the premiere company dedicated exclusively to natural Moringa nutritional supplements, beauty products and tea. "While clinical trials are necessary to show the definitive effect on the human body, this is overwhelmingly positive for Moringa oleifera."
Known as the "Miracle Tree," Moringa oleifera's naturally-occurring antioxidants support the prevention of cancer and other diseases that attack the body's cells. Antioxidants, such as those found in Moringa Source's comprehensive line of Moringa products, aids cell restoration, which can combat oxidative stress by preventing free radicals from reacting and causing damage to cells.
The ORAC test on Moringa Source Moringa Oleifera leaf powder was conducted by independent lab Brunswick Laboratories. "By commissioning the study, it was our intent to draw more positive attention to the rich antioxidants found in the phenomenal Moringa plant," Fitzpatrick said. "Equally as important is the fact that Moringa Source's Moringa Powder contains more than 27% protein including the 8 essential amino acids, 25 vitamins and minerals as well as many other beneficial phyto-nutrients."
In addition to ranking first in antioxidant content, Moringa oleifera contains over 90 nutrients such as vitamins, proteins, amino acids, iron and calcium, offering unique anti-aging and energy-enhancing characteristics. The benefits of this "super plant" have been embraced as one of nature's most powerful sources of nutrients to support healthy living in the India, Africa and South America for more than 2,000 years. Health and wellness experts in the U.S., including Dr. Mehmet Oz, and in Europe have begun recommending Moringa oleifera for sustained energy and general wellness. Moringa oleifera was recently featured on "The Dr. Oz Show" as a way to jump-start the day and re-energize your life.
Moringa is a raw food and is naturally vegan, caffeine-free and gluten-free. The World Health Organization and other charitable organizations currently use Moringa as a basis for daily nutritional programs helping malnourished children.
Why moringa can reduce sickle cell crisis-–Experts
- Active Adults: on-the-go lifestyle. Working 8-10 hours a day and trying to keep up with other activities.
- Senior Adults: lessened ability to absorb nutrients, lower metabolism, and less energy.
- Children: hard to get them to eat right even if you cook healthy food for them; they often snub vegetables.
- Parents: no time to think about their own nutrition; too busy.
- Teenagers: immortal attitude, don’t think about and don’t care about what fast food does to them; not worried about the future.
- Athletes: need extra protein and other nutrients for their training regimen.
- Travelers: fatigue; most meals are fast food.
- Overweight But Undernourished: even when food is plentiful, it doesn’t always provide proper nutrition.
- Vegetarians: sometimes it’s hard to get the right kind of protein in the right amounts.
- Lactating Mothers: Moringa has been shown to increase milk supply.
Hippocrates c.460 - 377 BC
Father of Modern Medicine
“Moringa Cures Stroke, Pressure and Asmah”
Retired Colonel Dr. Ansu R. Sankoh has disclosed that Moringa a traditional plant can cure strokes, asthma, blood pressure, Ulcer and other sickness.
The Retired Colonel made this statement over the week end during presentation of Moringa seedlings to household farmers in Bumbuna for onward planting in their back yard garden and farm to multiply and later use.
Dr. Ansu R. Sankoh who is presently operating a health center in Bumbuna town in Tonkolili district said he had tried Moringa herbs on some of his patients with strokes and even HIV. The result and their response he said shows some success and improvement.
The Retired Colonel called on Sierra Leoneans to be using Moringa constantly to help improve their health status.
Speaking at the distribution exercise, the publicity and communication officer Caritas Alfred Haroun Thullah said, Moringa tree can cure many diseases in man. Mr. Thullah said Moringa also promotes environmental, geographical and medical values.
The Caritas communications officer assured beneficiaries and community people of Caritas taking the lead in Moringa campaign as part of their disaster risk reduction program. He urged them to cultivate the seedlings and treat them with respect and care.
Director Hydro Movies Joseph Musa Koroma said, he read about Moringa long ago and discovered its importance. This he went on, “as part of our agricultural program, we now have a radio program where we discuss about Moringa and its importance,” he said. He assured Caritas of his movies intervention in ensuring they take Moringa to more communities in Tonkolili district.
By Mohamed Kabba
Bharali R, J Tabassum, MRH Azad (2003) Chemomodulatory effect of Moringa oleifera, Lam, on hepatic carcinogen metabolizing enzymes, antioxidant parameters and skin papillomagenesis in mice. Asian Pacific Journal of Cancer Prevention 4: 131-139
Murakami A, Y Kitazono, S Jiwajinda, K Koshimizu, and H Ohigashi (1998) Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter- induced Epstein-Barr virus activation. Planta Medica 64: 319-323